The Heisenberg uncertainty relationship for the intensity and phase of light describes a fundamental shot noise limit that cannot be surpassed with classical states of light. Two- mode squeezed light sources exhibiting continuous variable entanglement allow us to reduce the noise floor in optically transduced sensors that utilize a single quadrature of the optical field, enabling greater signal to noise ratios than are possible in the best possible classical sensors. I will present some of our recent results demonstrating quantum enhanced sensitivity for applications ranging from magnetometry to plasmonic sensing to atomic force microscopy. I will also discuss some of our recent research efforts exploring quantum nanophotonics with plasmonic nanostructures and single photon emitters in low-dimensional materials. I will close with a brief perspective on the potential for hybrid quantum systems incorporating both continuous-variable squeezed light sources and nanophotonic discrete-variable quantum light sources.