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DTSTART;TZID=US/Eastern:20100813T133000
DTEND;TZID=US/Eastern:20100813T143000
SUMMARY:Microcantilever Based Sensors for Detection of Biological and Chemical Species -- Dr. Pranav Shrotriya
DESCRIPTION:NanoSEC Seminar. Micromechanical cantilever based surface stress sensors have demonstrated tremendous sensitivity tonon-labeled detection of chemical and biochemical compounds. The sensing strategy involves coatingone surface of a microcantilever with a receptor species that has high affinity for the analyte molecule ofinterest. The presence of the analyte is detected by resolving the surface stress change associated withabsorption/adsorption of analyte molecules on the sensitized surface. While a number of studies havebeen undertaken to explore potential uses of the cantilever sensors, their widespread application isseverely limited due to: 1) lack of integration of all the components in a single miniature device; and 2)incomplete understanding of the molecular mechanisms governing the sensor response. We address theselimitations through development of an interferometry based surface stress sensing approach andmultiscale models to identify mechanism governing surface stress generation. I will discuss our results onsurface stress changes associated with two model systems: 1) formation of monomolecular alkanethiolfilms on gold surfaces; and 2) hybridization of surface immobilized DNA molecules. Insight gained fromthe results on the model systems is currently being used to investigate aptamer-modified microcantileversfor detection of controlled substances and novel approach on immobilizing receptor molecules thatmaximizes the surface stress changes.
LOCATION:Auditorium, Riverbend Research Laboratory South
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