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DTSTART;TZID=US/Eastern:20100304T160000
DTEND;TZID=US/Eastern:20100304T170000
SUMMARY:In silico modeling of molecular effects caused by non-synonymous variations in human DNA -- Emil Alexov
DESCRIPTION:Departmental Colloquium. Dr. Phillip Stancil will host Dr. Emil Alexov of the University of Clemson Department of Physics and Astronomy this week. His talk is entitled "In silico modeling of molecular effects caused by non-synonymous variations in human DNA."Human DNA sequence differs among individuals and the most common variations are known as single
nucleotide polymorphisms, or SNPs. Studies have shown that non-synonymous coding SNPs (nsSNPs -
SNPs occurring in protein coding regions which lead to amino acid substitutions) can be responsible for
many human diseases. They can also cause the natural differences among individuals by affecting the
structure, function, interactions as well as other properties of expressed proteins. The ability of predicting
whether a given nsSNP is disease-causing or harmless would be of great importance both in early
detection of genetic diseases for high-risk patients and facilitating future development of drugs to alter
the harmful effects of these nsSNP mutations.In this talk, I will present an overview of the existing approaches to model the effects of nsSNPs,
emphasising on modeling the effects affecting protein-protein interactions. I will demonstrate that these
effects can not be predicted without detailed computer simulations due to the natural plasticity of protein
structures. Further I will focus on a particular disease, the Snyder-Robinson syndrome, which was shown
to be caused by malfunction of a particular protein, the spermine sythase protein. Three missense
mutations have been clinically identified, but so far no explanation of the effects on molecular level is
available. I will present a detailed computational analysis of the molecular effects caused by these
mutations and link the corresponding findings to the function of spermine sythase protein.
LOCATION:202 Physics
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